Guidelines for diagnosis, prevention, and treatment of hand eczema

Jacob P Thyssen; Marie L A Schuttelaar; Jose H Alfonso; Klaus E Andersen; Irena Angelova-Fischer; Bernd W M Arents; Andrea Bauer; Richard Brans; Alicia Cannavo; Wianda A Christoffers; Marie-Noelle Crépy; Peter Elsner; Manigé Fartasch; Francesca Larese Filon; Ana M Giménez-Arnau; Margarida Gonçalo; Maria G Guzmán-Perera; Carsten R Hamann; Wolfram Hoetzenecker; Jeanne Duus Johansen; Swen M John; Amalia C M Kunkeler; Suzana Ljubojevic Hadzavdic; Sonja Molin; Rosemary Nixon; Jart A F Oosterhaven; Thomas Rustemeyer; Esther Serra-Baldrich; Mili Shah; Dagmar Simon; Christoph Skudlik; Radoslaw Spiewak; Skaidra Valiukevičienė; Angelique N Voorberg; Elke Weisshaar; Tove Agner

doi:10.1111/cod.14035

Guidelines for diagnosis, prevention, and treatment of hand eczema

Contact Dermatitis. 2022 May;86(5):357-378. doi: 10.1111/cod.14035. Epub 2022 Mar 3.

Authors

Jacob P Thyssen¹, Marie L A Schuttelaar², Jose H Alfonso^{3

4}, Klaus E Andersen⁵, Irena Angelova-Fischer⁶, Bernd W M Arents⁷, Andrea Bauer⁸, Richard Brans^{9

10}, Alicia Cannavo¹¹, Wianda A Christoffers¹², Marie-Noelle Crépy^{13

14}, Peter Elsner¹⁵, Manigé Fartasch¹⁶, Francesca Larese Filon¹⁷, Ana M Giménez-Arnau¹⁸, Margarida Gonçalo¹⁹, Maria G Guzmán-Perera²⁰, Carsten R Hamann²¹, Wolfram Hoetzenecker²², Jeanne Duus Johansen²³, Swen M John^{9

10}, Amalia C M Kunkeler²⁴, Suzana Ljubojevic Hadzavdic²⁵, Sonja Molin²⁶, Rosemary Nixon²⁷, Jart A F Oosterhaven², Thomas Rustemeyer²⁸, Esther Serra-Baldrich²⁹, Mili Shah³⁰, Dagmar Simon³¹, Christoph Skudlik^{9

10}, Radoslaw Spiewak³², Skaidra Valiukevičienė³³, Angelique N Voorberg², Elke Weisshaar³⁴, Tove Agner¹

Affiliations

¹ Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
² Department of Dermatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
³ Department of Dermatology, Oslo University Hospital, Oslo, Norway.
⁴ Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway.
⁵ Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
⁶ Department of Dermatology, Comprehensive Allergy Center, Kepler University Hospital, Linz, Austria.
⁷ Dutch Association for People with Atopic Dermatitis, Nijkerk, The Netherlands.
⁸ Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
⁹ Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.
¹⁰ Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany.
¹¹ Contact Dermatitis and Occupational Dermatoses, Hospital de Clínicas "José de San Martín", Buenos Aires University, Buenos Aires, Argentina.
¹² Department of Dermatology, Isala Dermatologic Center, Zwolle, The Netherlands.
¹³ Department of Occupational and Environmental Diseases, University Hospital of Centre of Paris, Hotel-Dieu Hospital, AP-HP, Paris, France.
¹⁴ Department of Dermatology, University Hospital of Centre of Paris, Cochin Hospital, AP-HP, Paris, France.
¹⁵ Department of Dermatology, University Hospital Jena, Jena, Germany.
¹⁶ Institute for Prevention and Occupational Medicine (IPA) of the German Social Accident Insurance, Department of Clinical and Experimental Occupational Dermatology, Ruhr University Bochum, Bochum, Germany.
¹⁷ Clinical Unit of Occupational Medicine, University of Trieste, Trieste, Italy.
¹⁸ Department of Dermatology, Hospital del Mar, IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain.
¹⁹ Clinic of Dermatology - University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
²⁰ Department of Dermatology, Hospital Angeles del Pedregal, Mexico City, Mexico.
²¹ Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
²² Department of Dermatology, Kepler University Hospital and Kepler University Linz, Linz, Austria.
²³ Department of Dermatology and Allergy, National Allergy Research Centre, Herlev-Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
²⁴ Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
²⁵ Department of Dermatology and Venereology, University Hospital Center Zagreb, Zagreb, Croatia.
²⁶ Division of Dermatology, Queen's University, Kingston, Ontario, Canada.
²⁷ Occupational Dermatology Research and Education Centre, Skin Health Institute, Melbourne, Victoria, Australia.
²⁸ Department of Dermatology-Allergology and Occupational Dermatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
²⁹ Department of Dermatology, Sant Pau Hospital, Universitat Autonoma Barcelona, Barcelona, Spain.
³⁰ Liverpool University Hospitals NHS Trust, Liverpool, UK.
³¹ Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
³² Department of Experimental Dermatology and Cosmetology, Jagiellonian University Medical College, Krakow, Poland.
³³ Department of Skin and Venereal Diseases, Lithuanian University of Health Sciences, Kaunas, Lithuania.
³⁴ Division of Occupational Dermatology, Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.

PMID: 34971008
DOI: 10.1111/cod.14035

Abstract

Background: Hand eczema is a common inflammatory skin disorder. Health care providers need continuously updated information about the management of hand eczema to ensure best treatment for their patients.

Objectives: To update the European Society of Contact Dermatitis guideline on the diagnosis, prevention, and treatment on of hand eczema.

Method: The Guideline Development Group (GDG) was established on behalf of the ESCD. A call for interest was launched via the ESCD website and via the ESCD members' mailing list. Appraisal of the evidence for therapeutic and preventive interventions was applied and a structured method of developing consensus was used and moderated by an external methodologist. The final guideline was approved by the ESCD executive committee and was in external review on the ESCD webpage for 1 month.

Results: Consensus was achieved for several statements and management strategies.

Conclusion: The updated guideline should improve management of hand eczema.

Keywords: allergic contact dermatitis; guideline; hand eczema; irritant contact dermatitis; prevention; treatment.

MeSH terms

Dermatitis, Allergic Contact* / diagnosis
Dermatitis, Allergic Contact* / prevention & control
Eczema* / diagnosis
Eczema* / prevention & control
Hand Dermatoses* / diagnosis
Hand Dermatoses* / prevention & control
Humans
Patch Tests

Grants and funding

No support was given by any medical company for development of this document. All meetings were virtual meetings, therefore there were no costs. All participants in the working group filled in a structured form to declare financial or non-financial interests. Disclosures are given in the Supporting information. The Guidelines were approved by the executive committee of the ESCD in October 2021.