Generation of human induced pluripotent stem cell lines from four unrelated healthy control donors carrying European genetic background

Aurore Girardeau; Diane Atticus; Robin Canac; Bastien Cimarosti; Amandine Caillaud; Caroline Chariau; Floriane Simonet; Bertrand Cariou; Flavien Charpentier; Jean-Baptiste Gourraud; Vincent Probst; Nadjet Belbachir; Laurence Jesel; Patricia Lemarchand; Julien Barc; Richard Redon; Nathalie Gaborit; Guillaume Lamirault

doi:10.1016/j.scr.2021.102647

Generation of human induced pluripotent stem cell lines from four unrelated healthy control donors carrying European genetic background

Stem Cell Res. 2022 Mar:59:102647. doi: 10.1016/j.scr.2021.102647. Epub 2021 Dec 28.

Authors

Aurore Girardeau¹, Diane Atticus¹, Robin Canac¹, Bastien Cimarosti¹, Amandine Caillaud¹, Caroline Chariau², Floriane Simonet¹, Bertrand Cariou¹, Flavien Charpentier¹, Jean-Baptiste Gourraud¹, Vincent Probst¹, Nadjet Belbachir³, Laurence Jesel⁴, Patricia Lemarchand¹, Julien Barc¹, Richard Redon¹, Nathalie Gaborit¹, Guillaume Lamirault⁵

Affiliations

¹ Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.
² Université de Nantes, CHU Nantes, INSERM, CNRS, SFR Santé, FED 4203, INSERM UMS 016, CNRS UMS 3556, F-44000 Nantes, France.
³ Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
⁴ CHU Strasbourg, Service de Cardiologie, Strasbourg, France.
⁵ Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France. Electronic address: guillaume.lamirault@univ-nantes.fr.

PMID: 34999420
DOI: 10.1016/j.scr.2021.102647

Abstract

Four human induced pluripotent stem cell (hiPSC) lines have been generated from healthy control European donors, and validated. This resource represents a useful tool for stem cell-based research, as references for developmental studies and disease modeling linked to any type of human tissue and organ, in an ethnical-, sex- and age-matched context. They providea reliable in-vitro model for single cell- and tissue-based investigations, and are also a valuable tool for genome editing-based studies.