T cell responses to SARS-CoV-2 in healthy controls and primary immunodeficiency patients

Arnold Awuah; Ava Zamani; Fariba Tahami; Mark Davis; Louis Grandjean; Matthew Buckland; Kimberly Gilmour

doi:10.1093/cei/uxac001

T cell responses to SARS-CoV-2 in healthy controls and primary immunodeficiency patients

Clin Exp Immunol. 2022 Jan 10;207(3):336-339. doi: 10.1093/cei/uxac001. Online ahead of print.

Authors

Arnold Awuah¹, Ava Zamani², Fariba Tahami², Mark Davis¹, Louis Grandjean³, Matthew Buckland¹, Kimberly Gilmour¹

Affiliations

¹ Department of Immunology, Great Ormond Street Hospital (GOSH).
² Affiliate of Department of Immunology, GOSH.
³ Department of Infectious Diseases, GOSH.

Abstract

Understanding the T cell response to SARS-CoV-2 is key in patients who lack antibody production. We demonstrate the applicability of a functional assay to measure the T cell response in a cohort of patients with immunodeficiency.

Keywords: Antibody Deficiency; COVID19; Immune Deficiency; Immune Response; Proliferation; SARS-COV2; T-cell.