Ligand-Enabled C-H Olefination and Lactonization of Benzoic Acids and Phenylacetic Acids via Palladium Catalyst

Org Lett. 2022 Jan 28;24(3):821-825. doi: 10.1021/acs.orglett.1c04000. Epub 2022 Jan 13.

Abstract

A novel ligand propan-2-one O-(p-tolylcarbamoyl) oxime (L7) has been developed to promote C(sp2)-H olefination of benzoic acids and phenylacetic acids via a palladium catalyst. With the subsequent lactonization of the olefinated products through 1,4-addition, highly monoselective cyclic lactone products of benzofuranones and benzopyrones were obtained in moderate to excellent yields. The DFT calculation demonstrated that the novel ligand propan-2-one O-(p-tolylcarbamoyl) oxime (L7) could improve the C-H activation reaction to give cyclic lactone products elegantly.

Publication types

  • Research Support, Non-U.S. Gov't