mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells

Qun Chu; Feifei Liu; Yifang He; Xiaoyu Jiang; Yusheng Cai; Zeming Wu; Kaowen Yan; Lingling Geng; Yichen Zhang; Huyi Feng; Kaixin Zhou; Si Wang; Weiqi Zhang; Guang-Hui Liu; Shuai Ma; Jing Qu; Moshi Song

doi:10.1007/s13238-021-00898-9

mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells

Protein Cell. 2022 Sep;13(9):676-682. doi: 10.1007/s13238-021-00898-9. Epub 2022 Jan 17.

Authors

Qun Chu^#^{1

2

3

4}, Feifei Liu^#^{5

2

3}, Yifang He^#^{5

2

3

6}, Xiaoyu Jiang^#^{5

2

3

6}, Yusheng Cai^{5

2

3}, Zeming Wu^{5

2

3}, Kaowen Yan^{5

2

3}, Lingling Geng^{7

8}, Yichen Zhang^{5

2

3

6}, Huyi Feng⁴, Kaixin Zhou⁹, Si Wang^{7

8}, Weiqi Zhang^{2

7

10

11

6

8

12}, Guang-Hui Liu^{13

14

15

16

17

18}, Shuai Ma^{19

20

21}, Jing Qu^{22

23

24

25}, Moshi Song^{26

27

28

29}

Affiliations

¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
⁴ Chongqing Renji Hospital, University of Chinese Academy of Sciences, Chongqing, 400062, China.
⁵ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
⁶ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁷ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
⁸ Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
⁹ College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
¹⁰ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
¹¹ China National Center for Bioinformation, Beijing, 100101, China.
¹² Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 101408, China.
¹³ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁶ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.
¹⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
¹⁸ Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.
¹⁹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
²⁰ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
²¹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. mashuai@ioz.ac.cn.
²² State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
²³ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
²⁴ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. qujing@ioz.ac.cn.
²⁵ University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn.
²⁶ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
²⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
²⁸ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. songmoshi@ioz.ac.cn.
²⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Mechanistic Target of Rapamycin Complex 2 / metabolism
Multiprotein Complexes / metabolism
Neural Stem Cells* / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Rapamycin-Insensitive Companion of mTOR Protein / metabolism
TOR Serine-Threonine Kinases* / metabolism

Substances

Multiprotein Complexes
RICTOR protein, human
Rapamycin-Insensitive Companion of mTOR Protein
Mechanistic Target of Rapamycin Complex 2
Proto-Oncogene Proteins c-akt
TOR Serine-Threonine Kinases