Serum levels of lipocalin-2 are elevated at early times in African American relapsing remitting multiple sclerosis patients

J Neuroimmunol. 2022 Mar 15:364:577810. doi: 10.1016/j.jneuroim.2022.577810. Epub 2022 Jan 12.

Abstract

Previous studies showed that depleting Liver Kinase-B1 (LKB1) from astrocytes increased inflammatory factors lipocalin-2 (LCN2) and osteopontin (OPN) in EAE. A single nucleotide polymorphism (SNP) in STK11 (encoding LKB1) is a risk factor for MS, suggesting increased LCN2 or OPN contributes to risk. Serum LCN2 and OPN levels in African American female MS patients were higher than healthy controls, and while levels increased with disease duration in cases without the SNP, levels decreased with duration in cases with the SNP. Increased MS risk associated with the STK11 SNP may be due to higher LCN2 or OPN levels at early times.

Keywords: Biomarker; LCN2; Lipocalin-2; Multiple sclerosis; Osteopontin.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • AMP-Activated Protein Kinase Kinases / genetics*
  • Adult
  • Biomarkers / blood
  • Black or African American / genetics
  • Disease Progression
  • Female
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Lipocalin-2 / blood*
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / blood*
  • Multiple Sclerosis, Relapsing-Remitting / genetics*
  • Osteopontin / blood
  • Polymorphism, Single Nucleotide

Substances

  • Biomarkers
  • LCN2 protein, human
  • Lipocalin-2
  • SPP1 protein, human
  • Osteopontin
  • STK11 protein, human
  • AMP-Activated Protein Kinase Kinases