Prevalence and risk factors of lower limb amputations in patients with diabetic foot ulcers: A systematic review and meta-analysis

Beverly T Rodrigues; Venkat N Vangaveti; Ravindra Urkude; Erik Biros; Usman H Malabu

doi:10.1016/j.dsx.2022.102397

Prevalence and risk factors of lower limb amputations in patients with diabetic foot ulcers: A systematic review and meta-analysis

Diabetes Metab Syndr. 2022 Feb;16(2):102397. doi: 10.1016/j.dsx.2022.102397. Epub 2022 Jan 14.

Authors

Beverly T Rodrigues¹, Venkat N Vangaveti¹, Ravindra Urkude², Erik Biros¹, Usman H Malabu³

Affiliations

¹ Translational Research in Endocrinology and Diabetes, College of Medicine and Dentistry, James Cook University, Australia.
² Department of Neurology, Townsville University Hospital, Australia.
³ Translational Research in Endocrinology and Diabetes, College of Medicine and Dentistry, James Cook University, Australia; Department of Diabetes and Endocrinology, Townsville University Hospital, Australia. Electronic address: usman.malabu@jcu.edu.au.

PMID: 35085918
DOI: 10.1016/j.dsx.2022.102397

Abstract

Background and aims: The study aimed at determining prevalence and risk factors (RFs) of diabetic lower limb amputations (LLAs).

Methods: Electronic databases including PubMed, Medline, Web of Science, and Cochrane Library were searched from January 2003 to April 2021.

Results: Sixteen full-text published studies were reviewed. The prevalence of LLAs stood as high as 66%, with a combined prevalence of 19% (95% CI 10-29) using the random-effects model. The most prominent RFs for LLA were duration of diabetes mellitus (DM), age, renal impairment, and ethnic minority. Amongst Australians, Indigenous background is strongly associated with increased risk of the diabetic foot (DF) LLA.

Conclusions: LLAs are considerably prevalent amongst patients with the DF and occur at even higher rates in patients with multimorbidity.

Keywords: Amputations; Diabetic foot ulcers; Prevalence; Risk factors.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Amputation, Surgical / statistics & numerical data
Australia / epidemiology
Diabetes Mellitus* / epidemiology
Diabetes Mellitus* / surgery
Diabetic Foot* / epidemiology
Diabetic Foot* / surgery
Humans
Lower Extremity* / surgery
Prevalence
Risk Factors