Treatment patterns and economic burden among newly diagnosed cervical and endometrial cancer patients

Future Oncol. 2022 Mar;18(8):965-977. doi: 10.2217/fon-2021-0727. Epub 2022 Feb 2.

Abstract

Aim: This study evaluated treatment patterns, healthcare resource use and healthcare costs among newly diagnosed US patients with cervical or endometrial cancer. Materials & methods: The authors identified patients diagnosed between 2015 and 2018, described them by line of therapy (LOT), then summarized all-cause per patient per month healthcare resource use and healthcare costs per LOT. Results: Among 1004 patients with cervical cancer and 2006 patients with endometrial cancer, 65.2 and 71.4%, respectively, received at least LOT1. Common treatment modalities in LOT1 were surgery (cervical, 58.0%; endometrial, 92.6%), radiation therapy (cervical, 49.8%; 24.7%) and systemic therapy (cervical, 53.3%; endometrial, 26.1%). Mean per patient per month costs per LOT were pre-treatment (cervical, US$17,210; endometrial, US$14,601), LOT1 (cervical, US$10,929; endometrial, US$6859), LOT2 (cervical, US$15,183; endometrial, US$10,649) and LOT3+ (cervical, US$19,681; endometrial, US$9206). Conclusion: Overall, newly diagnosed patients with cervical or endometrial cancer received guideline-recommended treatment. Outpatient visits mainly drove healthcare costs across LOTs.

Keywords: cervical cancer; endometrial cancer; healthcare costs; newly diagnosed; real-world data; resource utilization; treatment patterns.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents / economics
  • Antineoplastic Agents / therapeutic use
  • Cohort Studies
  • Combined Modality Therapy
  • Early Detection of Cancer
  • Endometrial Neoplasms / diagnosis
  • Endometrial Neoplasms / economics
  • Endometrial Neoplasms / therapy*
  • Female
  • Guideline Adherence
  • Gynecologic Surgical Procedures / economics
  • Gynecologic Surgical Procedures / statistics & numerical data
  • Health Care Costs*
  • Health Services Accessibility*
  • Humans
  • Middle Aged
  • Radiotherapy / economics
  • Radiotherapy / statistics & numerical data
  • Retrospective Studies
  • United States
  • Uterine Cervical Neoplasms / diagnosis
  • Uterine Cervical Neoplasms / economics
  • Uterine Cervical Neoplasms / therapy*
  • Young Adult

Substances

  • Antineoplastic Agents

Grants and funding