[Evaluation of the in vitro activity of aztreonam on 1990 gram-negative bacterial strains recently isolated in Campania hospitals]

I Covelli; M Bolletti-Censi; A Fortunato; A Guarino; G Spagnoletti; G Amato; E Nani; D Anzivino; A Lavitola; E Gulletta

[Evaluation of the in vitro activity of aztreonam on 1990 gram-negative bacterial strains recently isolated in Campania hospitals]

Boll Ist Sieroter Milan. 1986;65(1):22-31.

[Article in Italian]

Authors

I Covelli, M Bolletti-Censi, A Fortunato, A Guarino, G Spagnoletti, G Amato, E Nani, D Anzivino, A Lavitola, E Gulletta

PMID: 3521671

Abstract

The in vitro activity of aztreonam, leader of a new class of antibiotics, the monobactams, has been investigated. The effectiveness of the new molecule on 1990 strains of Gram-negative clinical isolates has been compared to that of some other drugs widely utilized for the treatment of nosocomial infections. Aztreonam has shown the highest activity against all the tested strains, with a geometrical mean of MICs (MG) of 0.37 and a MIC 90 of 8 micrograms/ml.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Aztreonam / analogs & derivatives
Aztreonam / pharmacology*
Cefotaxime / pharmacology
Ceftazidime / pharmacology
Cross Infection / drug therapy
Gentamicins / pharmacology
Gram-Negative Bacteria / drug effects*
Humans
In Vitro Techniques
Microbial Sensitivity Tests
Piperacillin / pharmacology
Structure-Activity Relationship

Substances

Gentamicins
SQ 26180
Ceftazidime
Aztreonam
Cefotaxime
Piperacillin