System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory

Marek A Budzyński; Sheila S Teves

doi:10.1016/j.tibs.2022.03.005

System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory

Trends Biochem Sci. 2022 Jul;47(7):556-557. doi: 10.1016/j.tibs.2022.03.005. Epub 2022 Mar 17.

Authors

Marek A Budzyński¹, Sheila S Teves²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
² Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address: sheila.teves@ubc.ca.

PMID: 35307259
DOI: 10.1016/j.tibs.2022.03.005

Abstract

Topoisomerase 1 (Top1) relieves torsional stress on DNA, including from RNA Polymerase II (Pol II) transcription. A new study by Wiegard et al. uncovers an unexpected role of Top1 in the appropriate clearance of Pol II from mitotic DNA, allowing for a reset of transcriptional memory in the daughter cells.

Publication types

Comment

MeSH terms

DNA
DNA Replication
RNA Polymerase II* / metabolism
Transcription, Genetic*

Substances

DNA
RNA Polymerase II