Otolaryngologic Disease in Down syndrome

Marisa A Earley; Erica T Sher; Tess L Hill

doi:10.1016/j.pcl.2022.01.005

Otolaryngologic Disease in Down syndrome

Pediatr Clin North Am. 2022 Apr;69(2):381-401. doi: 10.1016/j.pcl.2022.01.005.

Authors

Marisa A Earley¹, Erica T Sher², Tess L Hill²

Affiliations

¹ UT Health San Antonio, 7703 Floyd Curl Drive MC 7777, San Antonio, TX 78229, USA. Electronic address: earleyma@uthscsa.edu.
² UT Health San Antonio, 7703 Floyd Curl Drive MC 7777, San Antonio, TX 78229, USA.

PMID: 35337546
DOI: 10.1016/j.pcl.2022.01.005

Abstract

As the most common human chromosomal abnormality, Trisomy 21 is a condition that many otolaryngologists and likely all pediatric otolaryngologists will encounter during their careers. There are several considerations regarding airway obstruction, otologic conditions, anesthetic implications, and endocrine disorders that will impact the treatment of these patients. Further, there is increasing literature supporting the use of early instrumental assessment of swallowing, drug-induced sleep endoscopy at the time of first surgical intervention for sleep apnea, consideration of concurrent upper and lower airway evaluation, and early otologic management including potential surgical hearing rehabilitation.

Keywords: Down syndrome; Dysphagia; Hearing loss; Obstructive sleep apnea; Otolaryngology; Trisomy 21; Upper airway obstruction.

Publication types

Review

MeSH terms

Child
Down Syndrome* / complications
Down Syndrome* / diagnosis
Endoscopy
Hearing Tests
Humans
Otorhinolaryngologic Diseases* / diagnosis
Otorhinolaryngologic Diseases* / etiology
Otorhinolaryngologic Diseases* / therapy
Sleep Apnea, Obstructive* / surgery