Genetic and non-genetic risk factors associated with atrial fibrillation

Lindsay J Young; Steve Antwi-Boasiako; Joel Ferrall; Loren E Wold; Peter J Mohler; Mona El Refaey

doi:10.1016/j.lfs.2022.120529

Genetic and non-genetic risk factors associated with atrial fibrillation

Life Sci. 2022 Jun 15:299:120529. doi: 10.1016/j.lfs.2022.120529. Epub 2022 Apr 3.

Authors

Lindsay J Young¹, Steve Antwi-Boasiako¹, Joel Ferrall², Loren E Wold³, Peter J Mohler⁴, Mona El Refaey⁵

Affiliations

¹ The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
² The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA.
³ The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; College of Nursing, The Ohio State University, Columbus, OH, USA.
⁴ The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.
⁵ The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH, USA. Electronic address: Mona.elrefaey@osumc.edu.

Abstract

Atrial fibrillation (AF) is the most common arrhythmic disorder and its prevalence in the United States is projected to increase to more than twelve million cases in 2030. AF increases the risk of other forms of cardiovascular disease, including stroke. As the incidence of atrial fibrillation increases dramatically with age, it is paramount to elucidate risk factors underlying AF pathogenesis. Here, we review tissue and cellular pathways underlying AF, as well as critical components that impact AF susceptibility including genetic and environmental risk factors. Finally, we provide the latest information on potential links between SARS-CoV-2 and human AF. Improved understanding of mechanistic pathways holds promise in preventative care and early diagnostics, and also introduces novel targeted forms of therapy that might attenuate AF progression and maintenance.

Keywords: Atrial fibrillation; COVID-19; Environment; Genetics; Preventative care.

Publication types

Review

MeSH terms

Atrial Fibrillation* / epidemiology
Atrial Fibrillation* / genetics
COVID-19*
Humans
Incidence
Risk Factors
SARS-CoV-2
United States

Abstract

Publication types

MeSH terms

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