Myeloid-derived suppressor cells in COVID-19: A review

Yuliya V Perfilyeva; Yekaterina O Ostapchuk; Raikhan Tleulieva; Aykin Kali; Nurshat Abdolla; Vladimir K Krasnoshtanov; Anastassiya V Perfilyeva; Nikolai N Belyaev

doi:10.1016/j.clim.2022.109024

Myeloid-derived suppressor cells in COVID-19: A review

Clin Immunol. 2022 May:238:109024. doi: 10.1016/j.clim.2022.109024. Epub 2022 Apr 27.

Authors

Yuliya V Perfilyeva¹, Yekaterina O Ostapchuk², Raikhan Tleulieva³, Aykin Kali⁴, Nurshat Abdolla⁵, Vladimir K Krasnoshtanov⁶, Anastassiya V Perfilyeva⁷, Nikolai N Belyaev⁸

Affiliations

¹ M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, 86 Dosmukhamedov St., Almaty 050012, Kazakhstan; Almaty Branch of the National Center for Biotechnology, 14 Zhahanger St., Almaty 050054, Kazakhstan. Electronic address: perfilyevayulya@gmail.com.
² M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, 86 Dosmukhamedov St., Almaty 050012, Kazakhstan; Almaty Branch of the National Center for Biotechnology, 14 Zhahanger St., Almaty 050054, Kazakhstan.
³ M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, 86 Dosmukhamedov St., Almaty 050012, Kazakhstan.
⁴ M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, 86 Dosmukhamedov St., Almaty 050012, Kazakhstan; Al-Farabi Kazakh National University, 71 Al-Farabi Ave., Almaty 050040, Kazakhstan.
⁵ M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, 86 Dosmukhamedov St., Almaty 050012, Kazakhstan; Almaty Branch of the National Center for Biotechnology, 14 Zhahanger St., Almaty 050054, Kazakhstan; Al-Farabi Kazakh National University, 71 Al-Farabi Ave., Almaty 050040, Kazakhstan.
⁶ Kazakh Research Institute of Oncology and Radiology, 91 Abay Ave., Almaty 050000, Kazakhstan.
⁷ Institute of Genetics and Physiology, 93 Al-Farabi Ave., Almaty 050060, Kazakhstan.
⁸ Saint-Petersburg Pasteur Institute, 14 Mira St., St. Petersburg 197101, Russia.

Abstract

Coronavirus disease 2019 (COVID-19) is a potentially life-threatening infection characterized by excessive inflammation, coagulation disorders and organ damage. A dysregulated myeloid cell compartment is one of the most striking immunopathologic signatures of this newly emerged infection. A growing number of studies are reporting on the expansion of myeloid cells with immunoregulatory activities in the periphery and airways of COVID-19 patients. These cells share phenotypic and functional similarities with myeloid-derived suppressor cells (MDSCs), which were first described in cancer patients. MDSCs are a heterogeneous population of pathologically activated myeloid cells that exert immunosuppressive activities against mainly effector T cells. The increased frequency of these cells in COVID-19 patients suggests that they are involved in immune regulation during this infection. In this article, we review the current findings on MDSCs in COVID-19 and discuss the complex role of these cells in the immunopathology of COVID-19.

Keywords: COVID-19; Immunopathology; Myeloid-derived suppressor cell; SARS-CoV-2.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Humans
Inflammation
Myeloid-Derived Suppressor Cells*
SARS-CoV-2
T-Lymphocytes