Safety and Efficacy of Inpatient Diabetes Management with Non-insulin Agents: an Overview of International Practices

Curr Diab Rep. 2022 Jun;22(6):237-246. doi: 10.1007/s11892-022-01464-1. Epub 2022 May 4.

Abstract

Purpose of review: The field of inpatient diabetes has advanced significantly over the last 20 years, leading to the development of personalized treatment approaches. However, outdated guidelines still recommend the use of basal-bolus insulin therapy as the preferred treatment approach, and against the use of non-insulin anti-hyperglycemic agents.

Recent findings: Several observational and prospective randomized controlled studies have demonstrated that oral anti-hyperglycemic agents are widely used in the hospital, including studies of DPP-4 agents and GLP-1 agonists. With advances in the field of inpatient diabetes management, a paradigm shift has occurred, from an approach of recommending "basal-bolus regimens" for all patients to a more precision medicine option for hospitalized non-critically ill patients with type 2 diabetes.

Keywords: Hospital diabetes; Inpatient hyperglycemia.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Blood Glucose
  • Diabetes Mellitus, Type 2* / drug therapy
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Inpatients
  • Insulin / therapeutic use
  • Prospective Studies

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin