CD8+ Tregs kill pathogenic cells to avert autoimmunity

Dan Hu; Gopal Murugaiyan

doi:10.1016/j.it.2022.04.006

CD8⁺ Tregs kill pathogenic cells to avert autoimmunity

Trends Immunol. 2022 Jun;43(6):415-416. doi: 10.1016/j.it.2022.04.006. Epub 2022 May 5.

Authors

Dan Hu¹, Gopal Murugaiyan²

Affiliations

¹ Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: dan_hu@rics.bwh.harvard.edu.
² Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

PMID: 35527183
DOI: 10.1016/j.it.2022.04.006

Abstract

Mouse Ly49⁺CD8⁺ regulatory T cells (Tregs) can subdue autoreactive CD4⁺ T cells to suppress autoimmunity. Recently, Li et al. demonstrated that killer-cell immunoglobulin-like receptor (KIR)⁺CD8⁺ T cells are the human equivalent of Ly49⁺CD8⁺ regulatory T cells and kill pathogenic CD4⁺ T cells, which can be increased in certain human autoimmune diseases and viral infections.

Keywords: CD8(+) Tregs; T cells; autoimmunity.

Publication types

Comment

MeSH terms

Animals
Autoimmune Diseases*
Autoimmunity*
CD8-Positive T-Lymphocytes
Humans
Mice
Receptors, KIR
T-Lymphocytes, Regulatory

Substances

Receptors, KIR