Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study

Hiba Fatayer; Rachel L O'Connell; Finian Bannon; Charlotte E Coles; Ellen Copson; Ramsey I Cutress; Rajiv V Dave; Matthew D Gardiner; Margaret Grayson; Christopher Holcombe; Sheeba Irshad; Gareth W Irwin; Ciara O'Brien; Carlo Palmieri; Abeer M Shaaban; Nisha Sharma; Jagdeep K Singh; Ian Whitehead; Shelley Potter; Stuart A McIntosh; NeST Study Research Collaborative

doi:10.1093/bjs/znac131

Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study

Br J Surg. 2022 Aug 16;109(9):800-803. doi: 10.1093/bjs/znac131.

Authors

Hiba Fatayer¹, Rachel L O'Connell², Finian Bannon³, Charlotte E Coles⁴, Ellen Copson⁵, Ramsey I Cutress⁵, Rajiv V Dave⁶, Matthew D Gardiner^{7

8}, Margaret Grayson⁹, Christopher Holcombe¹, Sheeba Irshad^{10

11}, Gareth W Irwin¹², Ciara O'Brien^{13

14}, Carlo Palmieri^{15

16}, Abeer M Shaaban¹⁷, Nisha Sharma¹⁸, Jagdeep K Singh¹⁹, Ian Whitehead¹, Shelley Potter^{20

21}, Stuart A McIntosh²²; NeST Study Research Collaborative

Collaborators

NeST Study Research Collaborative:
H Curry, E Iddles, M Mahmood, Y Masannat, J Schneider, L Simpson, M Sidapra, L Baker, H Capitelli-McMahon, M Hughes, A Isaac, B Skelly, C Sirianni, N Hirst, R Linforth, A Botes, T Robinson, T Schrire, J Alfred, H Lennon, D Dumitru, E Kleidi, F Hoar, E MacInnes, K Sharma, T Alaguthurai, N Chand, C A Farulla, A Hayward, B Pearce, M Tatterton, S Laws, J Iqbal, M S Mirza, K V Sainarayanan, L Humphreys, S Tayeh, S Jones, A Ansari, R Bate, B C J Wei, B Gurung, F M T Leone, C Mitchell, G Mondani, S Pilgrim, T Sun, G Boundouki, R Broadbent, A Khan, F Morgans-Slader, J Rai, R Soulsby, H Cain, R Thomas, B Elsberger, G Walls, S Cadwell-Sneath, J Couch, M D'Auria, C Grundy, S Hitchin, H Khout, F Latief, J Mondani, A Nessa, G Oni, L Sawers, S S Rajan, Q Tan, L Whisker, A Ghoneima, M Rezacova, N Marikakis, L Ballance, U Andaleeb, N Basu, T Hubbard, A Maxwell, M Roland, C Weerasinghe, Q Ain, G Bitsakou, C Chamberlain, N Chopra, A Micha, C Norman, P Padmanabhan, N Patani, K Shanthakunalan, E St John, S Jafferbhoy, C Bransgrove, A Hussein, J Livingstone, O Waker, J Hack, S Hadad, J Newell, A Heetun, A Hargreaves, E Rahman, R Vidya

Affiliations

¹ Liverpool Breast Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
² Department of Breast Surgery, Royal Marsden NHS Foundation Trust, Sutton, UK.
³ Centre for Public Health, Queen's University Belfast, Institute of Clinical Science, Belfast, UK.
⁴ Department of Oncology, University of Cambridge, Cambridge, UK.
⁵ Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton and University Hospital Southampton, Southampton, UK.
⁶ Nightingale Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
⁷ Department of Plastic Surgery, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK.
⁸ Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
⁹ Northern Ireland Cancer Research Consumer Forum, Northern Ireland Cancer Trials Network, Belfast City Hospital, Belfast, UK.
¹⁰ Guy's Cancer Centre, Guy's and St Thomas' NHS Trust, London, UK.
¹¹ School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
¹² Breast Surgery Department, Belfast City Hospital, Belfast Health and Social Care Trust, Belfast, UK.
¹³ Department of Medical Oncology, Christie Hospital NHS Foundation Trust, Manchester, UK.
¹⁴ School of Medical Sciences Faculty of Biology, Medicine and Health University of Manchester, Manchester, UK.
¹⁵ University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Department of Molecular and Clinical Cancer Medicine, Liverpool, UK.
¹⁶ Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.
¹⁷ Department of Pathology, Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, UK.
¹⁸ Breast Unit, St James's Hospital, Leeds, UK.
¹⁹ Surrey and Sussex Healthcare NHS Trust, East Surrey Hospital, Redhill, UK.
²⁰ Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, Bristol, UK.
²¹ Bristol Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
²² Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.

No abstract available

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Breast Neoplasms* / drug therapy
Breast Neoplasms* / surgery
Chemotherapy, Adjuvant
Female
Humans
Mastectomy, Segmental
Neoadjuvant Therapy*
Treatment Outcome
United Kingdom / epidemiology

MeSH terms

Grants and funding