Total Synthesis of the Repeating Units of O-Specific Polysaccharide of Pseudomonas chlororaphis subsp. aureofaciens UCM B-306 via One-Pot Glycosylation

Org Lett. 2022 May 27;24(20):3696-3701. doi: 10.1021/acs.orglett.2c01318. Epub 2022 May 13.

Abstract

Herein we report the first total syntheses of the trisaccharide-repeating units of Pseudomonas chlororaphis subsp. aureofaciens UCM B-306 via a one-pot assembly of the core trisaccharide structure. The rare-sugar-containing trisaccharide-repeating units are comprised of d-bacillosamine, 2-amino-2-deoxy-d-galacturonic acid or amide, and d-rhamnose units linked through three consecutive α-linkages. The total syntheses of two repeating units were completed starting from d-mannose via a longest-linear sequence of 27 steps in 5.8% and 4.4% overall yields, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glycosylation
  • O Antigens* / chemistry
  • Pseudomonas* / chemistry
  • Trisaccharides

Substances

  • O Antigens
  • Trisaccharides

Supplementary concepts

  • Pseudomonas chlororaphis subsp. aureofaciens