Ketotherapy: Cutting carbs to treat cancer

Megan D Radyk; Samuel A Kerk; Costas A Lyssiotis

doi:10.1016/j.medj.2022.01.005

Ketotherapy: Cutting carbs to treat cancer

Med. 2022 Feb 11;3(2):87-89. doi: 10.1016/j.medj.2022.01.005.

Authors

Megan D Radyk¹, Samuel A Kerk², Costas A Lyssiotis³

Affiliations

¹ Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
² Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Doctoral Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.
³ Doctoral Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address: clyssiot@med.umich.edu.

Abstract

Dietary interventions hold promise in cancer treatments. However, clinical application has been limited by a lack of mechanistic understanding of the metabolic effects. In this issue, Yang et al. use mouse models and isotope tracing to demonstrate that the ketogenic diet induces reductive stress and primes pancreatic tumors for chemotherapy.¹.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Carbohydrates
Diet, Ketogenic*
Disease Models, Animal
Mice
Pancreatic Neoplasms* / drug therapy

Substances

Carbohydrates

Abstract

Publication types

MeSH terms

Substances

Grants and funding