Update on Pregnancy Following Breast Cancer Diagnosis and Treatment

Marta Perachino; Francesca Poggio; Luca Arecco; Eva Blondeaux; Stefano Spinaci; Camilla Marrocco; Alessia Levaggi; Matteo Lambertini

doi:10.1097/PPO.0000000000000599

Update on Pregnancy Following Breast Cancer Diagnosis and Treatment

Cancer J. 2022 May-Jun;28(3):176-182. doi: 10.1097/PPO.0000000000000599.

Authors

Marta Perachino, Francesca Poggio¹, Luca Arecco, Eva Blondeaux², Stefano Spinaci³, Camilla Marrocco², Alessia Levaggi², Matteo Lambertini

Affiliations

¹ U.O. Oncologia Medica 2, IRCCS Ospedale Policlinico San Martino.
² From the U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino.
³ Division of Breast Surgery, Ospedale Villa Scassi e ASL3, Genova, Italy.

PMID: 35594464
DOI: 10.1097/PPO.0000000000000599

Abstract

Survivorship has become a crucial component in breast cancer care. For women who have not completed their family planning, conceiving at the end of anticancer treatments should not be discouraged but might be challenging. Oncofertility counseling should be offered at the time of diagnosis to all patients, in order to inform them about the potential treatment-induced gonadotoxicity as well as the available strategies for fertility preservation, thus allowing to increase the chances of a future pregnancy. This article reports an updated overview on the current state of the art on pregnancy in women with prior breast cancer diagnosis and treatment, with a main focus on the issues faced by patients with history of hormone receptor-positive disease and BRCA carriers.

Trial registration: ClinicalTrials.gov NCT03155997 NCT00833963 NCT02032823 NCT02308085.

Publication types

Review

MeSH terms

Breast Neoplasms* / diagnosis
Breast Neoplasms* / therapy
Counseling
Female
Fertility Preservation*
Humans
Pregnancy

Associated data

ClinicalTrials.gov/NCT03155997
ClinicalTrials.gov/NCT00833963
ClinicalTrials.gov/NCT02032823
ClinicalTrials.gov/NCT02308085