Mechanical waves in myelinated axons

Biomech Model Mechanobiol. 2022 Aug;21(4):1285-1297. doi: 10.1007/s10237-022-01591-4. Epub 2022 Jun 15.

Abstract

The propagation of an action potential in nerves is accompanied by mechanical and thermal effects. Several mathematical models explain the deformation of the unmyelinated axon wall (a mechanical wave). In this paper, the deformation of the myelinated axon wall is studied. The mathematical model is inspired by the mechanics of microstructured materials with multiple scales. The model involves a Boussinesq-type equation together with a modification that describes the process in the myelin sheath. The dispersion analysis of such a model explains the behaviour of group and phase velocities. In addition, it is shown how dissipative effects may influence the process. Numerical calculations demonstrate the changes in velocities and wave profiles in the myelinated axon wall.

Keywords: Mechanical waves; Microstructured media; Nerve signals; Wave propagation.

MeSH terms

  • Action Potentials / physiology
  • Axons* / physiology
  • Myelin Sheath* / physiology