Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2

Jonathan M Cohen; Michael J Carter; C Ronny Cheung; Shamez Ladhani; Evelina Paediatric Inflammatory Multisystem Syndrome Temporally related to SARS-CoV-2 (PIMS-TS) Study Group

doi:10.1093/cid/ciac553

Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2

Clin Infect Dis. 2023 Feb 8;76(3):e518-e521. doi: 10.1093/cid/ciac553.

Authors

Jonathan M Cohen^{1

2}, Michael J Carter^{3

4}, C Ronny Cheung^{5

6}, Shamez Ladhani^{7

8}; Evelina Paediatric Inflammatory Multisystem Syndrome Temporally related to SARS-CoV-2 (PIMS-TS) Study Group

Affiliations

¹ Paediatric Immunology and Infectious Diseases, Evelina London Children's Hospital, London, United Kingdom.
² University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
³ School of Life Course and Population Sciences, King's College London, London, United Kingdom.
⁴ Paediatric Intensive Care Unit, Evelina London Children's Hospital, London, United Kingdom.
⁵ General Paediatrics Department, Evelina London Children's Hospital, London, United Kingdom.
⁶ Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
⁷ Immunisation Division, UK Health Security Agency, London, United Kingdom.
⁸ Paediatric Infectious Diseases Research Group, St George's University of London, London, United Kingdom.

Abstract

Little is known about the risk of multisystem inflammatory syndrome in children (MIS-C) with different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. In southeast England, MIS-C rates per confirmed SARS-CoV-2 infections in children aged 0-16 years were 56% lower (rate ratio [RR], 0.34 [95% confidence interval {CI}, .23-.50]) during prevaccine Delta, 66% lower (RR, 0.44 [95% CI, .28-.69]) during postvaccine Delta, and 95% lower (RR, 0.05 [95% CI, .02-.10]) during the Omicron period.

Keywords: COVID-19; MIS-C; PIMS-TS; SARS-CoV-2; coronavirus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Child
Connective Tissue Diseases*
Coronavirus Infections*
Humans
Pneumonia, Viral*
SARS-CoV-2
Systemic Inflammatory Response Syndrome / epidemiology

Supplementary concepts

SARS-CoV-2 variants
pediatric multisystem inflammatory disease, COVID-19 related