Advances of bacteria-based delivery systems for modulating tumor microenvironment

Shuping Li; Hua Yue; Shuang Wang; Xin Li; Xiaojun Wang; Peilin Guo; Guanghui Ma; Wei Wei

doi:10.1016/j.addr.2022.114444

Advances of bacteria-based delivery systems for modulating tumor microenvironment

Adv Drug Deliv Rev. 2022 Sep:188:114444. doi: 10.1016/j.addr.2022.114444. Epub 2022 Jul 9.

Authors

Shuping Li¹, Hua Yue², Shuang Wang³, Xin Li³, Xiaojun Wang⁴, Peilin Guo², Guanghui Ma⁵, Wei Wei⁶

Affiliations

¹ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, PR China.
² State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China.
³ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
⁴ Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, PR China.
⁵ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: ghma@ipe.ac.cn.
⁶ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: weiwei@ipe.ac.cn.

PMID: 35817215
DOI: 10.1016/j.addr.2022.114444

Abstract

The components and hospitable properties of tumor microenvironment (TME) are associated with tumor progression. Recently, TME modulating vectors and strategies have garnished significant attention in cancer therapy. Although a pilot work has reviewed TME regulation via nanoparticle-based delivery systems, there is no systematical review that summarizes the natural bacteria-based anti-tumor system to modulate TME. In this review, we conclude the strategies of bacterial carriers (including whole bacteria, bacterial skeleton and bacterial components) to regulate TME from the perspective of TME components and hospitable properties, and the clinical trials of bacteria-mediated cancer therapy. Current challenges and future prospects for the design of bacteria-based carriers are also proposed that provide critical insights into this natural delivery system and related translation from the bench to the clinic.

Keywords: Bacterial carriers; Hospitable properties; Hypoxia; Immune activation; Immune tolerance/suppression; TME components; TME modulation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bacteria
Humans
Nanoparticles*
Neoplasms* / drug therapy
Neoplasms* / pathology
Tumor Microenvironment / physiology