Informed Chemical Classification of Organophosphorus Compounds via Unsupervised Machine Learning of X-ray Absorption Spectroscopy and X-ray Emission Spectroscopy

J Phys Chem A. 2022 Jul 28;126(29):4862-4872. doi: 10.1021/acs.jpca.2c03635. Epub 2022 Jul 15.

Abstract

We analyze an ensemble of organophosphorus compounds to form an unbiased characterization of the information encoded in their X-ray absorption near-edge structure (XANES) and valence-to-core X-ray emission spectra (VtC-XES). Data-driven emergence of chemical classes via unsupervised machine learning, specifically cluster analysis in the Uniform Manifold Approximation and Projection (UMAP) embedding, finds spectral sensitivity to coordination, oxidation, aromaticity, intramolecular hydrogen bonding, and ligand identity. Subsequently, we implement supervised machine learning via Gaussian process classifiers to identify confidence in predictions that match our initial qualitative assessments of clustering. The results further support the benefit of utilizing unsupervised machine learning as a precursor to supervised machine learning, which we term Unsupervised Validation of Classes (UVC), a result that goes beyond the present case of X-ray spectroscopies.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Ligands
  • Organophosphorus Compounds*
  • Spectrometry, X-Ray Emission
  • Unsupervised Machine Learning*
  • X-Ray Absorption Spectroscopy

Substances

  • Ligands
  • Organophosphorus Compounds