The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice

Xin Qi; Xin-Tong Lu; Xi-Han Sun; Chang-Qing Lin; Cheng-Bi Cui

doi:10.1016/j.crfs.2022.06.010

The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice

Curr Res Food Sci. 2022 Jul 8:5:1140-1147. doi: 10.1016/j.crfs.2022.06.010. eCollection 2022.

Authors

Xin Qi¹, Xin-Tong Lu², Xi-Han Sun³, Chang-Qing Lin⁴, Cheng-Bi Cui^{1

2

3}

Affiliations

¹ Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, China.
² Department of Food Processing and Safety, College of Agricultural, Yanbian University, Yanji, 133002, China.
³ Food Science and Engineering, Convergence College, Yanbian University, Yanji, 133002, China.
⁴ Medical College, Yanbian University, Yanji, 133002, China.

Abstract

In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes.

Keywords: Hypoglycemic; Mechanism; Sedum aizoon L.; Total flavonoids.