Role of the PD-1 and PD-L1 axis in COVID-19

Future Microbiol. 2022 Sep:17:985-988. doi: 10.2217/fmb-2022-0103. Epub 2022 Jul 28.

Abstract

Tweetable abstract Severe COVID-19 patients display dysregulated expression of checkpoint molecules PD-1 and its ligand PD-L1, suggesting that these checkpoint molecules could be considered as prognostic markers and therapeutic targets in severe cases of COVID-19.

Keywords: COVID-19; PD-1; PD-L1; SARS-CoV-2; adaptive immune cells; immune checkpoint molecules; innate immune cells.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • B7-H1 Antigen* / metabolism
  • COVID-19*
  • Humans
  • Programmed Cell Death 1 Receptor / metabolism*

Substances

  • B7-H1 Antigen
  • Programmed Cell Death 1 Receptor