Long-term normothermic perfusion of human livers for longer than 12 days

Artif Organs. 2022 Dec;46(12):2504-2510. doi: 10.1111/aor.14372. Epub 2022 Aug 5.

Abstract

In this case report, we preserved human livers for up to 13 days under normothermic conditions using a modified commercial perfusion system. Two whole livers were split into two left lateral segment grafts and two extended right grafts without interruption to blood flow and then perfused on separate machines. Not only does this provide the basis for a meaningful study of liver function in the long term, but this could also facilitate the development of a model of ex situ liver regeneration.

Keywords: ex situ machine perfusion; long-term perfusion; split livers.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Liver / blood supply
  • Liver / surgery
  • Liver Transplantation*
  • Organ Preservation
  • Perfusion