Case Report: Insulinoma Co-Existing With Type 2 Diabetes - Advantages and Challenges of Treatment With Endoscopic Ultrasound-Guided Radiofrequency Ablation

Front Endocrinol (Lausanne). 2022 Jul 22:13:957369. doi: 10.3389/fendo.2022.957369. eCollection 2022.

Abstract

The coexistence of insulinoma and type 2 diabetes is rare and the diagnostic process is often challenging. Continuous glucose monitoring system devices, which are more readily available nowadays, provide a useful tool for the diagnosis and evaluation of treatment response. Curative surgery is often the mainstay of treatment for insulinoma. Here, we report a Chinese patient with insulinoma diagnosed simultaneously with type 2 diabetes. His insulinoma was managed with endoscopic ultrasound guided-radiofrequency ablation (EUS-RFA) and the patient achieved complete resolution of hypoglycaemic episodes. The case illustrates that while EUS-RFA is an emerging non-invasive treatment modality for pancreatic lesions, limitations exist especially when histological confirmation is essential.

Keywords: continuous glucose monitoring; endoscopic ultrasound; insulinoma; radio frequency ablation; type 2 diabetes.

Publication types

  • Case Reports

MeSH terms

  • Blood Glucose
  • Blood Glucose Self-Monitoring
  • Diabetes Mellitus, Type 2* / complications
  • Humans
  • Insulinoma* / complications
  • Insulinoma* / diagnostic imaging
  • Insulinoma* / surgery
  • Pancreatic Neoplasms* / complications
  • Pancreatic Neoplasms* / diagnostic imaging
  • Pancreatic Neoplasms* / surgery
  • Radiofrequency Ablation*
  • Ultrasonography, Interventional

Substances

  • Blood Glucose