Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology

J Natl Compr Canc Netw. 2022 Aug;20(8):925-951. doi: 10.6004/jnccn.2022.0040.

Abstract

Differentiated thyroid carcinomas is associated with an excellent prognosis. The treatment of choice for differentiated thyroid carcinoma is surgery, followed by radioactive iodine ablation (iodine-131) in select patients and thyroxine therapy in most patients. Surgery is also the main treatment for medullary thyroid carcinoma, and kinase inhibitors may be appropriate for select patients with recurrent or persistent disease that is not resectable. Anaplastic thyroid carcinoma is almost uniformly lethal, and iodine-131 imaging and radioactive iodine cannot be used. When systemic therapy is indicated, targeted therapy options are preferred. This article describes NCCN recommendations regarding management of medullary thyroid carcinoma and anaplastic thyroid carcinoma, and surgical management of differentiated thyroid carcinoma (papillary, follicular, Hürthle cell carcinoma).

MeSH terms

  • Adenocarcinoma* / drug therapy
  • Carcinoma, Neuroendocrine
  • Humans
  • Iodine Radioisotopes / therapeutic use
  • Iodine* / therapeutic use
  • Thyroid Carcinoma, Anaplastic*
  • Thyroid Neoplasms* / diagnosis
  • Thyroid Neoplasms* / pathology
  • Thyroid Neoplasms* / therapy

Substances

  • Iodine Radioisotopes
  • Iodine

Supplementary concepts

  • Thyroid cancer, medullary