Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp3)-P Bond Formation

Cheng-Kun Li; Ze-Kun Tao; Adedamola Shoberu; Wei Zhang; Jian-Ping Zou

doi:10.1021/acs.orglett.2c02454

Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp³)-P Bond Formation

Org Lett. 2022 Aug 19;24(32):6083-6087. doi: 10.1021/acs.orglett.2c02454. Epub 2022 Aug 11.

Authors

Cheng-Kun Li¹, Ze-Kun Tao¹, Adedamola Shoberu¹, Wei Zhang², Jian-Ping Zou¹

Affiliations

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University, Suzhou, Jiangsu 215123, China.
² Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts 02125, United States.

PMID: 35950907
DOI: 10.1021/acs.orglett.2c02454

Abstract

A Cu^I-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp³)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H₂O₂, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H-P(O) compounds.