Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage

Mickael Vourc'h; Antoine Roquilly; Adrien Foucher; Christelle Retiere; Fanny Feuillet; Sapna Devi; Hamish E G McWilliam; Cecile Braudeau; Geraldine Bourreille; Abderrahman Hachani; Dermot O'Kane; Scott N Mueller; Joseph Ischia; Jean-Christian Roussel; Jean-Christophe Rigal; Regis Josien; Bertrand Rozec; Jose A Villadangos; Karim Asehnoune

doi:10.1016/j.jacbts.2022.02.019

Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage

JACC Basic Transl Sci. 2022 Jun 1;7(7):627-638. doi: 10.1016/j.jacbts.2022.02.019. eCollection 2022 Jul.

Authors

Mickael Vourc'h^{1

2

3}, Antoine Roquilly^{2

4}, Adrien Foucher^{2

4}, Christelle Retiere⁵, Fanny Feuillet⁶, Sapna Devi¹, Hamish E G McWilliam¹, Cecile Braudeau⁷, Geraldine Bourreille⁸, Abderrahman Hachani¹, Dermot O'Kane⁹, Scott N Mueller¹, Joseph Ischia⁹, Jean-Christian Roussel¹⁰, Jean-Christophe Rigal³, Regis Josien⁷, Bertrand Rozec^{3

11}, Jose A Villadangos¹, Karim Asehnoune^{2

4

12}

Affiliations

¹ Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.
² Nantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France.
³ Cardiac Surgery Intensive Care Unit, Hôpital Laennec, CHU Nantes, Nantes, France.
⁴ Surgical Intensive Care Unit, Hôtel Dieu, CHU Nantes, Nantes, France.
⁵ Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France and Etablissement Français du Sang Centre Pays de la Loire, Nantes, France and LabEx IGO "Immunotherapy, Graft, Oncology".
⁶ Plateforme de Méthodologie et Biostatistique, France, Université de Nantes, INSERM, SPHERE U1246, France.
⁷ CHU Nantes, Nantes Université, Laboratoire d'immunologie, CIMNA, and Nantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France.
⁸ Etablissement Français du Sang (EFS) Pays-de-Loire, Nantes, France.
⁹ Department of Surgery, Austin Health, The University of Melbourne and Australian Department of Urology, Austin Health, Heidelberg, Victoria, Australia.
¹⁰ Cardiac Surgery Department, Hôpital Laennec, CHU Nantes, Nantes, France.
¹¹ Nantes University, CHU Nantes, CNRS, Inserm, Institut du Thorax, Nantes, France.
¹² CHU de Nantes, Service d'Anesthésie Réanimation, Nantes, France.

Abstract

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.

Keywords: AKI, acute kidney injury; CPB, cardiopulmonary bypass; IRI, ischemia-reperfusion injury; MPO, myeloperoxidase; MRP_14, myeloid-related protein 14; PRBC, packed red blood cells; acute kidney injury; cardiac surgery; neutrophils; packed red blood cells; transfusion; transfusion safety; trogocytosis.