Lateralization in 11 C-Metomidate PET and outcome of adrenalectomy in primary aldosteronism

Abstract

Introduction: Subtype classification method is essential when considering adrenalectomy as a possible treatment for primary aldosteronism. We aimed to retrospectively evaluate surgical outcomes of primary aldosteronism in patients who had undergone ¹¹ C-metomidate positron emission tomography (¹¹ C-MTO-PET) for subtype classification.

Methods: Postoperative clinical and biochemical cure and histopathological diagnosis from biobank samples were retrospectively evaluated in 44 patients who had all undergone preoperative ¹¹ C-MTO-PET with or without adrenal venous sampling (AVS). We compared those operated based on ¹¹ C-MTO-PET alone and those with concordant or discordant lateralization in ¹¹ C-MTO-PET and AVS studies according to postoperative immunohistochemical findings and biochemical and clinical cure.

Results: Adrenalectomy side was based on ¹¹ C-MTO-PET alone in 14 cases and on AVS in 30 cases of whom 42 achieved complete and two partial biochemical cures. Among those who underwent AVS and were operated according to it, the two lateralization methods were concordant in 22 cases and discordant in 8 cases. Similar immunohistochemical profiles and cure rates were seen after ¹¹ C-MTO-PET alone or AVS-based operations. Respectively, those with concordant or discordant ¹¹ C-MTO-PET and AVS lateralization did not differ in surgical outcome. Together, we found errors of lateralization diagnostics with ¹¹ C-MTO-PET in 18% and with AVS in 3% among those eligible for adrenal surgery.

Conclusions: Outcomes of adrenalectomy based on clinically significant lateralization in ¹¹ C-MTO-PET alone correspond to those based on ¹¹ C-MTO-PET with concordant AVS lateralization. However, our results suggest that diagnosis of unilateral PA should be performed with caution with ¹¹ C-MTO-PET in case of discordant lateralization studies.

Keywords: 11C-Metomidate positron emission tomography; CYP11B2 immunostaining; adrenal venous sampling; primary aldosteronism; subtype classification in primary aldosteronism; surgical outcome.