Associated functional network connectivity between callous-unemotionality and cognitive and affective empathy

Abstract

Background: Low empathy is one component of affective impairments defining the antisocial youth phenotype callous-unemotional (CU) traits. Research suggests CU traits may be negatively associated with neural networks that are positively associated with cognitive and affective empathy - specifically the default mode (DMN), frontoparietal (FPN), and salience (SAL) networks. Determining which functional network connections are shared between CU traits and empathy could elucidate the extent to which CU traits shares neural substrates with cognitive versus affective empathy. The present study tested whether CU traits and both cognitive and affective empathy share network connections within and between the DMN, FPN, and SAL.

Methods: Participants (n = 112, aged 13-17, 43 % female) completed resting-state functional magnetic resonance imaging and self-reports for CU traits and empathy as part of a Nathan-Kline Institute study.

Results: Analyses revealed inverse associations with shared network connections between CU traits and both cognitive and affective empathy. Specifically, within-DMN connectivity negatively associated with CU traits, but positively associated with cognitive empathy; and between DMN-SAL connectivity positively associated with CU traits, but negatively associated with both cognitive and affective empathy. However, joint models revealed little variance explained by CU traits and empathy overlapped.

Limitations: The sample was cross-sectional collection with limited participants (n = 112) from the community that may not generalize to incarcerated adolescents.

Conclusions: Results demonstrate CU traits inversely associated with similar connectivity patterns as cognitive and affective empathy though prediction among constructs did not significantly overlap. Further investigation of these connections can inform a mechanistic understanding of empathy impairments in CU traits.

Keywords: Adolescents; Callous-unemotional traits; Empathy; Functional connectivity.