Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media

Int J Mol Sci. 2022 Aug 23;23(17):9529. doi: 10.3390/ijms23179529.

Abstract

The application of immobilized sulfuric acid on silica gel (H2SO4-SiO2) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts were obtained in high to excellent yields within 10 min in aqueous media under catalytic conditions. The key advantages of the process include a short reaction time, high yields, the catalyst's low cost, and the catalyst's reusability.

Keywords: aqueous media; immobilized sulfuric acid on silica gel; passerini reaction; α-acyloxycarboxamides.

MeSH terms

  • Catalysis
  • Silica Gel
  • Silicon Dioxide*
  • Sulfuric Acids*

Substances

  • Sulfuric Acids
  • Silica Gel
  • Silicon Dioxide
  • sulfuric acid