Is There a Place for Hyperbaric Oxygen Therapy?

Kinjal N Sethuraman; Ryan Smolin; Sharon Henry

doi:10.1016/j.yasu.2022.02.011

Is There a Place for Hyperbaric Oxygen Therapy?

Adv Surg. 2022 Sep;56(1):169-204. doi: 10.1016/j.yasu.2022.02.011.

Authors

Kinjal N Sethuraman¹, Ryan Smolin², Sharon Henry³

Affiliations

¹ University of Maryland Medical Center, Hyperbaric and Dive Medicine, 22 South Greene Street, Baltimore, MD 2120, USA.
² University of Maryland School of Medicine, 685 West Baltimore Street, Suite 150, Baltimore, MD 21201, USA.
³ University of Maryland Medical Center, R A Cowley Shock Trauma Center, Room T1R59, 22 South Greene Street, Baltimore, MD 21201, USA. Electronic address: sharon.henry@som.umaryland.edu.

PMID: 36096567
DOI: 10.1016/j.yasu.2022.02.011

Abstract

Hyperbaric oxygen therapy (HBOT) involves treating patients by providing 100% oxygen through inhalation while inside a treatment pressurized chamber. The oxygen acts as a drug and the hyperbaric chamber as the dosing device. The effect of hyperbaric hyperoxia is dose dependent and, therefore, treatment depth and duration are important when considering its use. HBOT can either be the primary method of treatment or used adjunctively to medications or surgical techniques. The underpinning physiology is to bring oxygen-rich plasma to hypoxic tissue, preventing reperfusion injury, strengthening immune responsiveness, and encouraging new collagen deposition as well as endothelial cell formation.

Keywords: Hyperbaric chamber; Hyperbaric oxygen therapy; Hypoxia; Inhalation.

Publication types

Review

MeSH terms

Humans
Hyperbaric Oxygenation* / methods
Oxygen

Substances

Oxygen