Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47

J Exp Med. 2022 Dec 5;219(12):e20220685. doi: 10.1084/jem.20220685. Epub 2022 Sep 16.

Abstract

Intercellular mitochondria transfer is a biological phenomenon implicated in diverse biological processes. However, the physiological role of this phenomenon remains understudied between erythroblasts and their erythroblastic island (EBI) macrophage niche. To gain further insights into the mitochondria transfer functions, we infused EBI macrophages in vivo into mice subjected to different modes of anemic stresses. Interestingly, we observed the occurrence of mitochondria transfer events from the infused EBI macrophages to early stages of erythroblasts coupled with enhanced erythroid recovery. Single-cell RNA-sequencing analysis on erythroblasts receiving exogenous mitochondria revealed a subset of highly proliferative and metabolically active erythroid populations marked by high expression of CD47. Furthermore, CD47 or Sirpα blockade leads to a decline in both the occurrence of mitochondria transfer events and their mediated erythroid recovery. Hence, these data indicate a significant role of mitochondria transfer in the enhancement of erythroid recovery from stress through the alteration of the bioenergetic profiles via CD47-Sirpα interaction in the early stages of erythroblasts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD47 Antigen* / metabolism
  • Energy Metabolism
  • Erythroblasts / metabolism
  • Erythropoiesis* / physiology
  • Mice
  • Mitochondria* / metabolism
  • RNA / metabolism
  • Receptors, Erythropoietin / metabolism
  • Single-Cell Analysis
  • Stress, Physiological

Substances

  • CD47 Antigen
  • Receptors, Erythropoietin
  • RNA