Assessing the utility of routine viral surveillance performed in children undergoing autologous stem cell transplantation at a single centre

David A Foley; Jessica Win See Wong; Aoife Keane; Shanti Ramachandran; Christopher C Blyth; Daniel K Yeoh

doi:10.1002/pbc.30012

Assessing the utility of routine viral surveillance performed in children undergoing autologous stem cell transplantation at a single centre

Pediatr Blood Cancer. 2022 Dec;69(12):e30012. doi: 10.1002/pbc.30012. Epub 2022 Sep 21.

Authors

David A Foley^{1

2

3}, Jessica Win See Wong⁴, Aoife Keane⁴, Shanti Ramachandran^{5

6}, Christopher C Blyth^{1

2

3

7}, Daniel K Yeoh^{7

8}

Affiliations

¹ Department of Microbiology, PathWest Laboratory Medicine, Nedlands, Western Australia, Australia.
² Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.
³ School of Medicine, University of Western Australia, Perth, Western Australia, Australia.
⁴ Department of General Paediatrics, Perth Children's Hospital, Perth, Western Australia, Australia.
⁵ Department of Oncology, Haematology and Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Western Australia, Australia.
⁶ School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.
⁷ Department of Infectious Diseases, Perth Children's Hospital, Perth, Western Australia, Australia.
⁸ Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.

PMID: 36129388
DOI: 10.1002/pbc.30012

Abstract

We assessed the utility of routine viral surveillance for cytomegalovirus, Epstein-Barr virus and human adenovirus in children <16 years, undergoing autologous stem cell transplantation (ASCT) at a single centre over a 10-year period. A total of 85 ASCT were performed in 65 patients. Routine viral surveillance resulted in a high number of tests performed (median 20 tests per ASCT), without any clinically significant viral detections. These data support the limited clinical utility of routine viral surveillance in children undergoing ASCT. Adopting a clinically driven approach for viral testing is likely to be both cost-effective and safe.

Keywords: Epstein-Barr virus; autologous stem cell transplantation; cytomegalovirus; human adenovirus; viral surveillance.

MeSH terms

Child
Cytomegalovirus Infections*
Epstein-Barr Virus Infections*
Hematopoietic Stem Cell Transplantation*
Herpesvirus 4, Human
Humans
Retrospective Studies
Stem Cell Transplantation / adverse effects
Stem Cell Transplantation / methods
Transplantation, Autologous