1 Bhavna Oza, MBBS, MRC Clinical Trials Unit, UCL Institute of Clinical Trials and Methodology, London, United Kingdom; Tim Eisen, PhD, Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom; Grant D. Stewart, MBChB, Department of Surgery, University of Cambridge, Cambridge, United Kingdom; Axel Bex, MD, Division of Surgery and Interventional Science, Royal Free London NHS Foundation Trust UCL, London, United Kingdom, Netherlands Cancer Institute, Amsterdam, the Netherlands; Patrick Royston, DSc, MRC Clinical Trials Unit, UCL Institute of Clinical Trials and Methodology, London, United Kingdom; and Angela Meade, DPhil, MRC Clinical Trials Unit, UCL Institute of Clinical Trials and Methodology, London, United Kingdom.