It takes a village to skew a lymph node

Emily E Thornton; Tal I Arnon

doi:10.1016/j.immuni.2022.09.008

It takes a village to skew a lymph node

Immunity. 2022 Oct 11;55(10):1751-1753. doi: 10.1016/j.immuni.2022.09.008.

Authors

Emily E Thornton¹, Tal I Arnon²

Affiliations

¹ University of Oxford, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine and Nuffield Department of Medicine, Oxford, UK.
² University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK. Electronic address: tal.arnon@kennedy.ox.ac.uk.

PMID: 36223721
DOI: 10.1016/j.immuni.2022.09.008

Abstract

Unconventional T cells (UTCs) play important roles in protecting barrier tissues. In this issue of Immunity, Ataide and colleagues show an additional function for these cells: populating downstream lymph nodes and skewing their cytokine profiles. This process allows tissues to adjust the function of draining lymph nodes through imprinting UTC cytokine production, subsequently influencing the immune responses that are triggered.

Publication types

Comment

MeSH terms

Cytokines
Lymph Nodes*
T-Lymphocytes*

Substances

Cytokines