Plasma Copy Number Alteration-Based Prognostic and Predictive Multi-Gene Risk Score in Metastatic Castration-Resistant Prostate Cancer

Cancers (Basel). 2022 Sep 28;14(19):4714. doi: 10.3390/cancers14194714.

¹ Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
² Department of the Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
³ Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
⁴ Department of Hematology and Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
⁵ Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
⁶ Department of Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
⁷ Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
⁸ Joseph J. Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI 53205, USA.
⁹ Division of Oncology, Department of Medicine, University of Utah Huntsman Cancer Center, Salt Lake City, UT 84112, USA.

Abstract

Prostate cancer (PCa) accounted for more than 34,000 deaths in US males [...].

Keywords: algorithm; cell free DNA; predictive biomarker; prognosis; prostate cancer.