Pregnancy Complications in Pandemics: Is Pregnancy-Related Anxiety a Possible Physiological Risk Factor?

Int J Environ Res Public Health. 2022 Sep 25;19(19):12119. doi: 10.3390/ijerph191912119.

Abstract

Background: Birth and pregnancy complications increased by 10.2% during the 2019 coronavirus (COVID-19) pandemic. Pregnant women are at high risk for anxiety, which might trigger physio-logical stress, leading to pregnancy complications.

Aim: This study aimed to investigate factors leading to antenatal anxiety during the COVID-19 pandemic. We also aimed to discuss our find-ings with regard to the current literature about pregnancy complications.

Methods: This cross-sectional study interviewed 377 pregnant women and assessed anxiety using a validated 7-item general anxiety disorder (GAD-7) scale. Anxiety was related to physiological and demo-graphic parameters. Anxiety was subdivided into pandemic- and pregnancy-related anxiety to minimize results bias.

Results: Our results showed that 75.3% of pregnant women were anxious. The mean GAD-7 score was 8.28 ± 5. Linear regression analysis showed that for every increase in the number of previous pregnancies, there was a 1.3 increase in anxiety level (p < 0.001). Women with no previous miscarriages were more anxious (p < 0.001). Surprisingly, pregnant women who were previously infected with COVID-19 were 6% less stressed. Pregnant women with comorbid-ities were more stressed (p < 0.001). Low income (p < 0.001) and age (p < 0.05) were the demo-graphic factors most significantly related to increased anxiety.

Conclusions: The prevalence of pregnancy-related anxiety increased threefold in Saudi Arabia due to the COVID-19 pandemic. Healthcare support should be available remotely during pandemics; pregnant women (especially those with comorbidities) should be educated about the risks of infection and complications to prevent anxiety-related complications during pregnancy.

Keywords: COVID-19; anxiety; mental health; pregnancy; women’s health.

MeSH terms

  • Anxiety / etiology
  • Anxiety Disorders / epidemiology
  • COVID-19* / epidemiology
  • Cross-Sectional Studies
  • Depression / epidemiology
  • Female
  • Humans
  • Pandemics / prevention & control
  • Pregnancy
  • Pregnancy Complications* / epidemiology
  • Pregnant Women
  • Risk Factors
  • SARS-CoV-2
  • Stress, Psychological / epidemiology

Grants and funding

This research received no external funding.