A Pilot Study on the Concentration, Distribution and Bioaccumulation of Polybrominated Diphenyl Ethers (PBDEs) in Tissues and Organs of Grassland Sheep

Int J Environ Res Public Health. 2022 Sep 26;19(19):12170. doi: 10.3390/ijerph191912170.

Abstract

Polybrominated diphenyl ether (PBDE) concentrations in various tissues and organs of grassland sheep from Inner Mongolia, China, were determined. The abilities of PBDEs binding to ovine serum albumin (OSA) and Cytochrome P450 enzyme (CYP3A24) were assessed by fluorescence spectroscopy and molecular docking simulations. The PBDE concentrations in the sheep tissue and organ samples were 33.4-167 pg/g dw. The distribution of PBDEs in sheep organs and tissues is affected not only by the function of organs and tissues, but also by the characteristics of PBDEs. Adipose tissue tends to bioaccumulate more-brominated BDEs (BDE-154, -153, and -183), but muscle tissues and visceral organs mainly bioaccumulate less-brominated BDEs. The distribution of PBDEs in visceral organs is mainly affected by the transport of ovine serum albumin (OSA) and the metabolism of CYP3A24 enzyme. The distribution of PBDEs in adipose tissue and brain is mainly affected by their logKOW.

Keywords: cytochrome P450 enzyme; molecular docking; molecular properties; ovine serum albumin; polybrominated diphenyl ethers; tissue distribution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bioaccumulation
  • China
  • Cytochrome P-450 Enzyme System
  • Environmental Monitoring
  • Grassland
  • Halogenated Diphenyl Ethers* / analysis
  • Molecular Docking Simulation
  • Pilot Projects
  • Serum Albumin
  • Sheep

Substances

  • Cytochrome P-450 Enzyme System
  • Halogenated Diphenyl Ethers
  • pentabromodiphenyl ether
  • Serum Albumin

Grants and funding

National College Student Innovation Program of Minzu University of China (grant no. GCCX2018110039). Fundamental Research Funds for the Central Universities (2021JCXK01).