Hepatitis B Virus (HBV) Replication During Tenofovir Therapy Is Frequent in Human Immunodeficiency Virus/HBV Coinfection

Eveline Hofmann; Bernard Surial; Noémie Boillat-Blanco; Huldrych F Günthard; Marcel Stöckle; Enos Bernasconi; Patrick Schmid; Alexandra Calmy; Franziska Suter-Riniker; Andri Rauch; Gilles Wandeler; Charles Béguelin; Swiss HIV Cohort Study

doi:10.1093/cid/ciac823

Hepatitis B Virus (HBV) Replication During Tenofovir Therapy Is Frequent in Human Immunodeficiency Virus/HBV Coinfection

Clin Infect Dis. 2023 Feb 18;76(4):730-733. doi: 10.1093/cid/ciac823.

Collaborators

Swiss HIV Cohort Study:
I Abela, K Aebi-Popp, A Anagnostopoulos, M Battegay, E Bernasconi, D L Braun, H C Bucher, A Calmy, M Cavassini, A Ciuffi, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, C A Fux, H F Günthard, A Hachfeld, D Haerry, B Hasse, H H Hirsch, M Hoffmann, I Hösli, M Huber, C R Kahlert, L Kaiser, O Keiser, T Klimkait, R D Kouyos, H Kovari, K Kusejko, G Martinetti, B Martinez de Tejada, C Marzolini, K J Metzner, N Müller, J Nemeth, D Nicca, P Paioni, G Pantaleo, M Perreau, A Rauch, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, G Wandeler, S Yerly

Affiliations

¹ Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
² Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
³ Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
⁴ Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
⁵ Department of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland.
⁶ Division of Infectious Diseases, Regional Hospital of Lugano, Lugano, Switzerland.
⁷ Division of Infectious Diseases, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.
⁸ Division of Infectious Diseases, Geneva University Hospital, University of Geneva, Geneva, Switzerland.
⁹ Institute for Infectious Diseases, University of Bern, Switzerland.
¹⁰ Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

PMID: 36242550
DOI: 10.1093/cid/ciac823

Abstract

In the Swiss HIV Cohort Study, 61 of 222 (27%) HIV-suppressed persons with chronic hepatitis B virus (HBV) infection had HBV replication after 2 years on tenofovir, of whom 77% were suppressed thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were predictors of persistent replication.

Keywords: coinfection; hepatitis B virus; human immunodeficiency virus; tenofovir; viral replication.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Coinfection*
DNA, Viral
HIV
HIV Infections*
Hepatitis B virus / genetics
Hepatitis B*
Hepatitis B, Chronic*
Humans
Tenofovir
Viral Load

Substances

Tenofovir
DNA, Viral

Grants and funding

177499/SNSF_/Swiss National Science Foundation/Switzerland