Visible-Light-Mediated Radical Silyl-Oximation of Activated Alkenes Using tert-Butyl Nitrite and Silanes

Org Lett. 2022 Nov 25;24(46):8568-8572. doi: 10.1021/acs.orglett.2c03644. Epub 2022 Nov 10.

Abstract

A metal-free radical 1,2-difunctionalization of activated alkenes with various silanes and tert-butyl nitrite is reported. The radical cascade occurs by light-promoted homolytic O-NO bond cleavage of tert-butyl nitrite and subsequent hydrogen atom abstraction by the alkoxyl radical from the silane. Silyl radical addition to the alkene and highly selective cross-coupling of the NO radical with the Si-adduct C-radical provide the silyl-oximation product in moderate to good yields. The reaction features good functional group tolerance and is easily scaled up.