Visualizing ligand bias at the Mu-opioid receptor

Catalina A Zamorano; Michael R Bruchas

doi:10.1016/j.cell.2022.10.013

Visualizing ligand bias at the Mu-opioid receptor

Cell. 2022 Nov 10;185(23):4251-4253. doi: 10.1016/j.cell.2022.10.013.

Authors

Catalina A Zamorano¹, Michael R Bruchas²

Affiliations

¹ Department of Pharmacology, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
² Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA. Electronic address: mbruchas@uw.edu.

PMID: 36368303
DOI: 10.1016/j.cell.2022.10.013

Abstract

Different opioid ligands can result in biased μ-opioid signaling, differentially activating signal cascades which produce analgesia, tolerance, or adverse effects. In this issue of Cell, Xu et al. used cryo-EM and computational simulations to understand how different μ-opioid receptor selective-ligands interact with key residues to produce downstream signaling.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Analgesics, Opioid* / adverse effects
Humans
Ligands
Pain*
Receptors, Opioid, mu / metabolism
Signal Transduction

Substances

Analgesics, Opioid
Ligands
Receptors, Opioid, mu

Abstract

Publication types

MeSH terms

Substances

Grants and funding