Copper-Catalyzed Radical Hydrazono-Phosphorylation of Alkenes

J Org Chem. 2022 Dec 2;87(23):15820-15829. doi: 10.1021/acs.joc.2c01832. Epub 2022 Nov 14.

Abstract

An efficient copper-catalyzed radical hydrazono-phosphorylation of alkenes with hydrazine derivatives and diarylphosphine oxides is described. The reaction provides a general and convenient method toward the synthesis of diverse β-hydrazonophosphine oxides in satisfactory yields. Based on conducted mechanistic experiments, a mechanism involving Ag-catalyzed oxidative generation of phosphinoyl radicals and subsequent addition to alkenes followed by Cu-assisted hydrazonation is proposed. Moreover, the practicability of the reaction is successfully demonstrated by its successful application on a gram scale.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes*
  • Catalysis
  • Copper*
  • Oxidation-Reduction
  • Oxides

Substances

  • Alkenes
  • Copper
  • Oxides