Multisystem cytomegalovirus end-organ disease in a patient with advanced HIV

Ruan Spies; Pierre Joubert; Dharshnee Chetty; Sipho Dlamini; Muhammed S Moosa

doi:10.4102/sajid.v37i1.468

Multisystem cytomegalovirus end-organ disease in a patient with advanced HIV

S Afr J Infect Dis. 2022 Nov 11;37(1):468. doi: 10.4102/sajid.v37i1.468. eCollection 2022.

Authors

Ruan Spies¹, Pierre Joubert¹, Dharshnee Chetty², Sipho Dlamini^{3

4}, Muhammed S Moosa^{1

4}

Affiliations

¹ Department of Medicine, New Somerset Hospital, Cape Town, South Africa.
² Division of Anatomical Pathology, Department of Pathology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
³ Division of Infectious Diseases and HIV Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
⁴ Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Abstract

Cytomegalovirus (CMV) infection is common in people living with HIV, but multisystem CMV end-organ disease (EOD) is rare following the introduction of effective antiretroviral therapy. We present the case of a patient with advanced HIV and multisystem manifestations of CMV EOD.

Contributions: This case report highlights the potential morbidity and mortality associated with CMV disease in patients with advanced HIV. Clinicians should be vigilant in considering CMV EOD in patients with advanced HIV and visual, neurological and gastointestinal symptoms.

Keywords: AIDS; CMV; HIV; cytomegalovirus; end-organ disease; opportunistic infection.