One-dimensional nanotube heterostructures with IrO2-stabilized La2IrO6 is obtained by an electrospinning approach. The La2IrO6/IrO2 catalyst exhibits superior catalytic activity and strong stability for the oxygen evolution reaction. The synergistic cooperation between the two types of Ir as the active sites in La2IrO6/IrO2 is demonstrated by in situ Raman spectrum and DFT calculation.