Serum vitamin D status and circulating irisin levels in older adults with sarcopenia

Yawen Wang; Yeqing Gu; Jian Huang; Hongmei Wu; Ge Meng; Qing Zhang; Li Liu; Shunming Zhang; Xuena Wang; Juanjuan Zhang; Shaomei Sun; Xing Wang; Ming Zhou; Qiyu Jia; Kun Song; Junsheng Huo; Bing Zhang; Gangqiang Ding; Peng Du; Kaijun Niu

doi:10.3389/fnut.2022.1051870

Serum vitamin D status and circulating irisin levels in older adults with sarcopenia

Front Nutr. 2022 Dec 7:9:1051870. doi: 10.3389/fnut.2022.1051870. eCollection 2022.

Authors

Yawen Wang^{1

2}, Yeqing Gu³, Jian Huang⁴, Hongmei Wu⁵, Ge Meng^{5

6}, Qing Zhang⁷, Li Liu⁷, Shunming Zhang⁵, Xuena Wang⁵, Juanjuan Zhang⁵, Shaomei Sun⁷, Xing Wang⁷, Ming Zhou⁷, Qiyu Jia⁷, Kun Song⁷, Junsheng Huo⁴, Bing Zhang⁴, Gangqiang Ding⁴, Peng Du¹, Kaijun Niu^{2

3

5

7

8

9}

Affiliations

¹ Air Force Medical Center of PLA, Beijing, China.
² School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
³ Nutrition and Radiation Epidemiology Research Center, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
⁴ Chinese Center for Disease Control and Prevention National Institute for Nutrition and Health, Beijing, China.
⁵ Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
⁶ Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
⁷ Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.
⁸ Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.
⁹ Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China.

Abstract

Background: Emerging evidence suggests sarcopenia, which is involved in the serum vitamin D deficiency and development of abnormal muscle metabolism, is predominately centered in the general older population. In the present study, we aimed to explore the relationship between the level of serum vitamin D and irisin concentrations in the older adults with sarcopenia.

Methods: A cross-sectional study was conducted which included 422 sarcopenia participants (146 males and 276 females). Sarcopenia was assessed according to the recommended diagnostic criteria of the Asia Working Group for Sarcopenia (AWGS). The levels of serum 25-hydroxyvitamin D (25(OH)D), 25-hydroxyvitamin D₂ (25(OH)D₂) and 25-hydroxyvitamin D₃ (25(OH)D₃) were determined by LC-MS/MS. Irisin levels were measured by enzyme-linked immunosorbent assay (ELISA). The relationship between serum concentration of vitamin D and irisin were determined using multiple linear regression analysis.

Results: After adjustment for potential confounding factors, a significant and positive relationship between changes in irisin across 25(OH)D, and 25(OH)D₃ was observed (standard regression coefficients of 0.150 and 0.151, respectively, P < 0.05). However, no significant relationship was observed between serum vitamin D concentrations and irisin levels in males.

Conclusions: This study demonstrated that a higher level of serum vitamin D is independently related to the increment of irisin in sarcopenia females, not in males. These investigations need to be verified in other large-scale prospective studies.

Keywords: 25-hydroxyvitamin D; 25-hydroxyvitamin D2; 25-hydroxyvitamin D3; irisin; sarcopenia.