Toward a fully implantable ecosystem for adaptive neuromodulation in humans: Preliminary experience with the CorTec BrainInterchange device in a canine model

Gerwin Schalk; Samuel Worrell; Filip Mivalt; Alexander Belsten; Inyong Kim; Jonathan M Morris; Dora Hermes; Bryan T Klassen; Nathan P Staff; Steven Messina; Timothy Kaufmann; Jörn Rickert; Peter Brunner; Gregory A Worrell; Kai J Miller

doi:10.3389/fnins.2022.932782

Toward a fully implantable ecosystem for adaptive neuromodulation in humans: Preliminary experience with the CorTec BrainInterchange device in a canine model

Front Neurosci. 2022 Dec 19:16:932782. doi: 10.3389/fnins.2022.932782. eCollection 2022.

Authors

Gerwin Schalk^{1

2}, Samuel Worrell¹, Filip Mivalt^{3

4}, Alexander Belsten^{5

6}, Inyong Kim³, Jonathan M Morris⁷, Dora Hermes⁸, Bryan T Klassen³, Nathan P Staff³, Steven Messina⁷, Timothy Kaufmann⁷, Jörn Rickert⁹, Peter Brunner^{5

6}, Gregory A Worrell^{3

8}, Kai J Miller^{1

8}

Affiliations

¹ Department of Neurosurgery, Mayo Clinic, Rochester, MN, United States.
² Chen Frontier Lab for Applied Neurotechnology, Tianqiao and Chrissy Chen Institute, Shanghai, China.
³ Department of Neurology, Mayo Clinic, Rochester, MN, United States.
⁴ Department of Biomedical Engineering, Brno University of Technology, Brno, Czechia.
⁵ Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, United States.
⁶ National Center for Adaptive Neurotechnologies, Albany, NY, United States.
⁷ Department of Neuroradiology, Mayo Clinic, Rochester, MN, United States.
⁸ Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States.
⁹ CorTec GmbH, Freiburg, Germany.

Abstract

This article describes initial work toward an ecosystem for adaptive neuromodulation in humans by documenting the experience of implanting CorTec's BrainInterchange (BIC) device in a beagle canine and using the BCI2000 environment to interact with the BIC device. It begins with laying out the substantial opportunity presented by a useful, easy-to-use, and widely available hardware/software ecosystem in the current landscape of the field of adaptive neuromodulation, and then describes experience with implantation, software integration, and post-surgical validation of recording of brain signals and implant parameters. Initial experience suggests that the hardware capabilities of the BIC device are fully supported by BCI2000, and that the BIC/BCI2000 device can record and process brain signals during free behavior. With further development and validation, the BIC/BCI2000 ecosystem could become an important tool for research into new adaptive neuromodulation protocols in humans.

Keywords: adaptive; brain–computer interface; invasive; neuromodulation; neurotechnology.

Abstract

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