Prostate-Specific Membrane Antigen PET Positivity in a Lung Mass: Diagnosis of Diffuse Large B-Cell Lymphoma

Clin Nucl Med. 2023 Feb 1;48(2):190-191. doi: 10.1097/RLU.0000000000004503.

Abstract

An 84-year-old man with nonmetastatic castrate-sensitive prostate cancer was referred for a 68Ga-prostate-specific membrane antigen (PSMA) PET/CT scan with a prostate-specific antigen level of 3.6 ng/mL for restaging. He was 22 years post-radical prostatectomy and had salvage radiation being managed with intermittent hormonal therapy. Imaging revealed a right lower lobe mass with increased PSMA uptake (SUVmax 6.2). Biopsy and subsequent immunostaining determined the mass to be diffuse large B-cell lymphoma. We report a case of diffuse large B-cell lymphoma diagnosed in the setting of PSMA positivity, highlighting awareness for oncologists and radiologists to know this possibility.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Gallium Radioisotopes
  • Humans
  • Lymphoma, Large B-Cell, Diffuse* / diagnostic imaging
  • Male
  • Positron Emission Tomography Computed Tomography / methods
  • Prostate / pathology
  • Prostate-Specific Antigen
  • Prostatectomy
  • Prostatic Neoplasms* / pathology

Substances

  • Prostate-Specific Antigen
  • Gallium Radioisotopes